Cause of Peyronies Disease

Penis injury or trauma to the penis is considered to be the most common cause for Peyronie’s disease (PD). However, no one seems to know for sure what happens that results in Peyronie’s or why some men get it while others do not. As a result, this makes it fairly difficult to give a definitive answer on both the prevention and treatment of the disease, i.e. if you don’t know what causes the problem, how can you prevent it or solve it? Most people agree that it is unlikely to control whether or not there was something that you could have done (or not done) to prevent yourself from ever contracting the disease.

Cause of Peyronies Disease – Starts Where?

Even though there is no certain answer on what brings about peyronies diseases, it is very commonly agreed by many (doctors and others, both professional and non-professional) that some of the most possible causes and the the most likely are as follows.

Penis Injury

Peyronies can be described as a type of disorder in the body’s ability to heal wounds. The most likely cause of this issue is therefore some kind of trauma or injury to the penis. The penis injury could be a significant one occurrence type of incident, e.g. sport accident, extremely vigorous sexual activity or invasive penile procedure such as a prostatectomy. When the disease shows very rapid signs of development, this is generally assumed to be the biggest factor on why this is so. Keep in mind though, that PD can also be caused by a series of minor penis injuries / traumas to the penis, e.g. through normal sexual intercourse over time.

For example, men whom are suffering from erectile dysfunction, but able to maintain enough of an erection to persistently penetrate their partner are more likely to have penis buckling incidents as the penis may not be sufficiently rigid. If still trying to pursue activity, the bending of the penis can become constant enough to start causing micro-damage which can lead to severe problems later on.

Low Testosterone And Peyronies Disease

Testosterone has been shown to influence wound healing and recent studies have suggested a significant relationship between low Testosterone and Peyronie’s disease, meaning that low testosterone levels may be contributing cause for this disorder.

This Peyronie’s Testosterone Study Opens in new window symbol showed 74.4% of Peyronie’s patients to have low testosterone level. The severity of the penis curvature was significantly greater for men with testosterone deficiency and for men with low free testosterone. Further studies are required to confirm this relationship but many doctors, including Dr. Mohit Khera, now recommend men with Peyronies to have their testosterone levels tested and treated if the results come back as lower than the standard. The identification, followed by correction, of low testosterone levels early on might even prevent the penis curvature to become greatly severe for some men.

Medication And Peyronie’s Disease

As with all medicines, a huge list of possible side effects generally accompany them. In most cases, there are more bad side effects than there are good possibilities that may come from the disorder. The number of medications that list Peyronie’s disease as possible side effects include; all beta-blockers, i.e. used to treat heart conditions and high blood pressure.

Pills in many colors

Commonly used beta-blockers include: Acebutolol (Sectral), Atenolol (Tenormin), Bisoprolol (Cardicor, Emcor, Zebeta), Metoprolol (Betaloc, Lopresor), Nadolol (Corgard), Nebivolol (Nebilet) and Propranolol (Inderal).

Other medications that list Peyronie’s disease as possible side effects include Interferon (used to treat multiple sclerosis) and Dilantin (anti-seizure medicine).

It is though important to keep things in perspective. The likelihood of developing Peyronie’s disease from taking above medicines is considered very low, if existing at all. Further studies are needed into this field.

However, if you need to take any of above medication you might want to raise your concerns with your doctor.

Other Possible Peyronie’s Causes

Peyronies is more common in some families so there might even be a genetic link, which has so far shown to be true. However, more studies need to be done before this can be a more definitive common.

One Family Study Opens in new window symbol even showed that pedigree analysis of three families suggested that the Peyronie’s syndrome is a male limited, autosomal dominant trait, i.e. you only need to have the abnormal gene from one of your biological parents to inherit the disease.

Furthermore, there seems to be link between Peyronie’s disease and other genetic disorders, like some connective tissue disorder. Around 30% of people suffering from Peyronies also have accumulated some form of hardened tissue in other parts of the body, mainly in the palm (Dupuytren’s contracture) of their hand or in the foot (Ledderhose’s disease).

There is also an indication that PD may have a vascular cause, i.e. more men with the disorder seem to be affected by high blood pressure (hypertension) and hardening of the arteries (atherosclerosis). Diabetes is also considered possible risk factor.

Some other possible causes have been raised but have not been shown (at least not yet) to be a likely cause of the disorder just yet. For example, a prospective study (2011) into the relationship between penile fractures and Peyronie’s disease showed that a Penile Fracture Opens in new window symbol did not induce the development of the condition.

The bottom line is that whatever the cause of Peyronie’s disease is… it is highly unlikely that you could have done, or not done, anything to prevent getting it. What matters now is that if you have it, you need to decide what you are going to do about it?


Additional sources: (Mayo Foundation for Medical Education and Research)